Facile and general synthesis of quaternary 3-aminooxindoles |
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Authors: | Marsden Stephen P Watson Emma L Raw Steven A |
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Institution: | School of Chemistry, University of Leeds, Leeds LS2 9JT, UK. s.p.marsden@leeds.ac.uk |
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Abstract: | A novel approach to the valuable quaternary 3-aminooxindole skeleton is reported on the basis of intramolecular arylation of enolates of substituted amino acids. The reaction tolerates dialkyl- and arylalkylamines as well as a range of carbon substituents (primary and secondary alkyl, aryl). The cyclization of N-indolyl-substituted substrates is accompanied by direct C-H arylation of the indole, leading to indolo-fused benzodiazepines. |
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