Thermal characterization and compatibility studies of norfloxacin for development of extended release tablets |
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Authors: | P R Oliveira L S Bernardi F S Murakami C Mendes M A S Silva |
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Institution: | 1.Department of Pharmaceutical Sciences, Health Science Centre,Federal University of Santa Catarina,Florianópolis,Brazil |
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Abstract: | Norfloxacin (NFX) is a synthetic antibacterial drug. The development of extended release tablets improves the patients’ comfort
and compliance, resulting in lower discontinuation of the therapy; with consequently decrease in bacterial resistance. In
the present work, the thermal behavior of NFX was investigated using TG and DSC techniques. Isothermal and non-isothermal
methods were employed to determine kinetic data of decomposition process. Compatibility studies between NFX and pharmaceutical
excipients, including three hydrophilic polymers were carried out in order to develop a new formulation of NFX to obtain extended
release tablets with an approved quality. |
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Keywords: | |
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