|
|||||
|
|
Biodistribution of gold nanoparticles in mouse lung following intratracheal instillation |
|
| Authors: | Evaldas Sadauskas Nicklas Raun Jacobsen Gorm Danscher Meredin Stoltenberg Ulla Vogel Agnete Larsen Wolfgang Kreyling Håkan Wallin |
| Institution: | 1. Department of Neurobiology, Institute of Anatomy, University of Aarhus, Building 1233/1234, DK-8000 Aarhus, Wilhelm Meyers Allé, Denmark 2. National Research Centre for the Working Environment, Lers? Parkallé 105, DK-2100 Copenhagen, Denmark 3. National Food Institute, Technical University of Denmark, M?rkh?j Bygade 19, DK-2860 S?borg, Denmark 4. Institute for Science, Systems and Models, University of Roskilde, DK-4000 Roskilde, Danmark 5. Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstaedter Landstr. 1, 85764 Neuherberg/Munich, Germany 6. Institute of Public Health, Copenhagen University, ?ster Farimagsgade 5, DK-1014 Copenhagen, Denmark |
| Abstract: | BackgroundThe fate of gold nanoparticles, 2, 40 and 100 nm, administered intratracheally to adult female mice was examined. The nanoparticles were traced by autometallography (AMG) at both ultrastructural and light microscopic levels. Also, the gold content was quantified by inductively coupled plasma mass spectrometry (ICP-MS) and neutron activation analysis (NAA). The liver is the major site of deposition of circulating gold nanoparticles. Therefore the degree of translocation was determined by the hepatic deposition of gold. Mice were instilled with 5 intratracheal doses of gold nanoparticles distributed over a period of 3 weeks and were killed 24 h after the last dose. One group of mice were given a single intratracheal dose and were killed after 1 h. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |