One step synthesis of Diflunisal using a Pd-diamine complex |
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Authors: | Tuula Kylmälä Jan Tois Youjun Xu Robert Franzén |
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Institution: | (1) Christian Doppler Laboratory for Microwave Chemistry (CDLMC) and Institute of Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, 8010 Graz, Austria |
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Abstract: | Diflunisal and Felbinac, two FDA-approved NSAIDs and other biphenyl carboxylic acids were prepared in one step by a simple
and clean Suzuki cross-coupling reaction using an easily synthesized, air and moisture stable, palladium-diamine complex.
The yield (93%) for the one-step preparation of Diflunisal is the best reported without using a glovebox and a phoshine-based
catalyst.
![MediaObjects/11532_2009_68_Fig1_HTML.jpg](/content/38H15W3X85L7J671/MediaObjects/11532_2009_68_Fig1_HTML.jpg) |
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