Total synthesis of viridiofungin A |
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Authors: | Morokuma Kenji Takahashi Keisuke Ishihara Jun Hatakeyama Susumi |
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Affiliation: | Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521, Japan. |
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Abstract: | Viridiofungin A, a member of amino alkyl citrate antibiotics from Trichoderma viride, was enantioselectively synthesized in naturally occurring form for the first time, employing regio- and stereoselective opening of the chiral glycidate with vinylmagnesium bromide and alkene cross metathesis of the citric acid core and hexadec-15-en-8-one as key steps. |
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