Oxa-enediynes: probing the electronic and stereoelectronic contributions to the Bergman cycloaromatization |
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| Authors: | Jones Graham B Wright Justin M Hynd George Wyatt Justin K Warner Philip M Huber Robert S Li Aiwen Kilgore Michael W Sticca Robert P Pollenz Richard S |
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| Affiliation: | Department of Chemistry, Northeastern University, Boston, Massachusetts 02115, USA. Gr.Jones@neu.edu |
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| Abstract: | Efficient routes to three classes of 10-membered oxa-enediynes are presented. The electronic and stereoelectronic contributions to half-lives are supported by density functional theory calculations. One member of this class cyclizes to give an isochroman which binds to and degrades the aryl hydrocarbon receptor (AhR). |
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