Design and synthesis of fused cyclic sulfamides-oxazolidinones |
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Authors: | Hamdi Rmedi |
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Institution: | 1. Science and Arts College, Department of Chemistry, Northern Border University, Turaif, 833, Saudi Arabia;2. Faculty of Sciences of Tunis, Laboratory of Structural Organic Chemistry, University of Tunis El Manar, 2092 Tunis, Tunisia |
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Abstract: | An efficient protocol for the synthesis of a new series of oxazolidin-2-ones containing sulfamide moieties is described. The synthesis was achieved in two reaction steps. The first was carried out under anhydrous conditions at 0?°C through a selective addition of an alcohol and primary amines to chlorosulfonylisocyanate to produce N-carboxylsulfamides in good yields. Under appropriate conditions of solvent, base and temperature, these intermediates underwent subsequent intramolecular cyclizations, giving exclusively the corresponding sulfamoyloxazolidinones. |
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Keywords: | Oxazolidinone Cyclic sulfamide 2 3-Dibromopropanol Chlorosulfonylisocyanate Science and Arts College Department of Chemistry Northern Border University Turaif 833 Saudi Arabia |
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