Total synthesis of anithiactins A-C and thiasporine A |
| |
Authors: | I Caroline Vaaland Emil Lindbäck Magne O Sydnes |
| |
Institution: | Faculty of Science and Technology, Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, NO-4036 Stavanger, Norway |
| |
Abstract: | The total syntheses of anithiactins A-C (1–3) and thiasporine A (4) have been achieved in good overall yields. The key reaction in the synthetic sequence was the Suzuki-Miyaura cross-coupling between 2-aminophenylboronic acid hydrochloride and methyl 2-bromothiazole-4-carboxylate forming the common intermediate methyl 2-(2-aminophenyl)thiazole-4-carboxylate (8), which could be further transformed by hydrolysis, alkylation, and aminolysis to give the four title natural products. This work represents the first total synthesis of anithiactin B (2) and C (3). |
| |
Keywords: | Natural product Total synthesis Thiazole Suzuki-Miyaura cross-coupling |
本文献已被 ScienceDirect 等数据库收录! |