Fusaspirols A-D,novel oxaspirol derivatives isolated from Fusarium solani B-18 |
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| Authors: | Nanang Rudianto Ariefta Hasna Tazkia Nikmawahda Takako Aboshi Tetsuya Murayama Keitaro Tawaraya Takuya Koseki Genta Katagi Yoshito Kakihara Yoshihito Shiono |
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| Affiliation: | 1. The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate, 020-8550, Japan;2. Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, 997-8555, Japan;3. Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Gadjah Mada, Bulaksumur, Yogyakarta, 55281, Indonesia;4. Division of Dental Pharmacology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Niigata, 951-8514, Japan |
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| Abstract: | Four novel compounds with γ-methylidene-spirobutanolide core, fusaspirols A-D, were isolated from the brown rice culture of Fusarium solani B-18. Their structures were established by extensive spectroscopic analyses of 1D/2D-NMR, HRESITOFMS, and chemical derivatization. The absolute configurations of secondary alcohols in fusaspirols A and D were determined using modified Mosher's ester method. Fusaspirol A and 4,9-di-O-acetylfusaspirol A activated a signaling pathway in osteoclastic differentiation of murine macrophage derived RAW264.7?cells. |
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| Keywords: | Endophyte Oxaspirols Fusaspirols |
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