Japonicones A-C: Three lindenane sesquiterpenoid dimers with a 12-membered ring core from Chloranthus japonicus |
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| Authors: | Huan Yan Xu-Jie Qin Xu-Hong Li Qian Yu Wei Ni Li He Hai-Yang Liu |
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| Institution: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China;2. Institute of Medicinal Chemistry and Chemical Biology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China;3. Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China |
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| Abstract: | Japonicones A–C (1–3), three new dimeric lindenane-type sesquiterpenoids featuring a rare 12-membered ring framework, were isolated from the whole plants of Chloranthus japonicus Sieb. Their structures and absolute configurations were unequivocally established by a combination of spectroscopic data, ECD calculation, and X-ray crystallography. Compounds 1–3 were evaluated for their DNA Topoisomerase Ⅰ (Top1) inhibitory, cytotoxic, and antibacterial activities. |
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| Keywords: | Lindenane sesquiterpenoid dimer Japonicones A-C ECD calculation |
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