| Abstract: | Aminoglycoside antibiotics are known to interact with a variety of RNA molecules, including ribosomal RNA, and the hammerhead ribozyme. These low molecular weight antibiotics have also been found to block the binding of HIV-1 Rev protein to its viral RNA recognition site, thereby inhibiting the production of the virus. But due to their toxicity, poor bioavailability, cellular penetration, and instability, they can not be used as an inhibitory drug direct ly. Therefore, it is highly desirable to synthesize aminoglycoside mimetics, which may be less toxic and more active than original aminoglycosides. |
