| 谷氨酸低分子量有机凝胶的药物控制释放行为 |
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| 引用本文： | 张莉,李远刚,段鹏飞,刘鸣华. 谷氨酸低分子量有机凝胶的药物控制释放行为[J]. 中国科学:化学, 2011, 0(8): 1352-1358 |
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| 作者姓名： | 张莉 李远刚 段鹏飞 刘鸣华 |
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| 作者单位： | 北京国家分子科学中心中国科学院化学研究所胶体与界面科学院重点实验室;西安科技大学化学与化工学院; |
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| 基金项目： | 国家自然科学基金(20803084); 国家重点基础研究发展计划(973计划)(2007CB808005,2009CB930802); 中国科学院资助 |
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| 摘 要： | 低分子量的有机胶凝剂组装形成的有机凝胶可应用于药物缓释体系.本研究中,使用亲水的钙黄绿素和疏水的布洛芬为模型分子,研究其在谷氨酸衍生物有机凝胶体系中的缓释行为.研究表明,与药物分子与有机胶凝剂简单混合的体系相比,亲水或疏水的药物分子在有机凝胶体系中的释放速度显著减缓.SEM的研究发现药物粒子嵌入在有机凝胶的三维网络中,因此,有机凝胶的三维网络结构可认为是实现药物缓慢释放的基质,药物分子从网络中的释放受限导致了其从有机凝胶中的缓释行为.
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| 关 键 词： | 谷氨酸 有机凝胶 控制释放 释放动力学 |
A L-glutamic acid based low molecular weight organogel as a vehicle for controlled drug release |
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| ZHANG Li ,LI YuanGang ,DUAN PengFei , LIU MingHua Beijing National Laboratory for Molecular Science ,CAS Key Laboratory of Colloid,Interface , Chemical Thermodynamics. A L-glutamic acid based low molecular weight organogel as a vehicle for controlled drug release[J]. Scientia Sinica Chimica, 2011, 0(8): 1352-1358 |
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| Authors: | ZHANG Li LI YuanGang DUAN PengFei & LIU MingHua Beijing National Laboratory for Molecular Science CAS Key Laboratory of Colloid Interface Chemical Thermodynamics |
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| Affiliation: | ZHANG Li 1,LI YuanGang 2,DUAN PengFei 1 & LIU MingHua 1 1 Beijing National Laboratory for Molecular Science (BNLMS),CAS Key Laboratory of Colloid,Interface and Chemical Thermodynamics,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,China 2 College of Chemistry and Chemical Engineering,Xi'an University of Science and Technology,Xi'an 710054,China |
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| Abstract: | Organogels formed by non-polymeric,low molecular weight organogelators have potentials to act as drug sustained release devices.Using hydrophilic calcein and lipophilic ibuprofen as model drugs,we studied the in vitro release behavior of the drugs loading into the glutamic acid based organogels.The in vitro release of drugs from the organogels is apparently slower than simple mixing.The SEM studies suggest that the drug particles are embedded into the networks formed by the self-assembled gelator fibers.The... |
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| Keywords: | glutamic acid organogels sustained release release kinetics |
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