| NaYF_4:Yb/Er-碳纳米管功能纳米材料的制备、表征及其在肿瘤细胞的靶向检测和治疗中的应用 |
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| 引用本文： | 陈庆涛,陈凤华,刘桂霞,董相廷,王进贤. NaYF_4:Yb/Er-碳纳米管功能纳米材料的制备、表征及其在肿瘤细胞的靶向检测和治疗中的应用[J]. 中国科学:化学, 2011, 0(5): 798-805 |
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| 作者姓名： | 陈庆涛 陈凤华 刘桂霞 董相廷 王进贤 |
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| 作者单位： | 长春理工大学化学与环境工程学院;中国科学院苏州纳米技术与纳米仿生研究所;郑州轻工业学院材料与化学工程学院; |
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| 基金项目： | 国家自然科学基金(50902100&51072026); 吉林省科技发展计划项目(20090528)的资助 |
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| 摘 要： | 将叶酸分子(FA)和2,3-二巯基丁二酸(DMSA)修饰的稀土上转换发光纳米粒子NaYF4:Yb/Er通过酰胺键偶联在多壁碳纳米管(MWCNT)的表面,得到NaYF4:Yb/Er-MWCNT-FA功能化复合纳米材料,并通过透射电子显微镜(TEM)、X射线衍射(XRD)、紫外-可见吸收光谱(UV-vis)、荧光光谱(PL)和共聚焦激光扫描显微镜等手段表征了其形貌、结构、发光性能和靶向成像性能.共聚焦激光扫描显微镜结果表明,相对于正常的HLF细胞,所制备的复合材料能够靶向检测叶酸受体高表达的宫颈癌Hela细胞.此外,将阿霉素进一步通过ππ堆垛吸附在此复合材料后,该载药体系具有明显的抗肿瘤活性,能够实现对肿瘤细胞的一步检测和治疗.
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| 关 键 词： | 纳米 NaYF4:Yb/Er 叶酸 碳纳米管 阿霉素 |
Functional nanomaterials of NaYF_4:Yb/Er-MWCNT: Synthesis, characterization and applications in targeted diagnosis and therapy of tumor cell |
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| CHEN QingTao,,CHEN FengHua,LIU GuiXia,DONG XiangTing , WANG JinXian School of Chemistry , Environmental Engineering,Changchun University of Science , Technology,Changchun ,China School of Material , Chemical Engineering,Zhengzhou University of Light Industry,Zhengzhou ,China Suzhou Institute of Nano-tech , Nano-bionics,Chinese Academy of Science,Suzhou ,China. Functional nanomaterials of NaYF_4:Yb/Er-MWCNT: Synthesis, characterization and applications in targeted diagnosis and therapy of tumor cell[J]. Scientia Sinica Chimica, 2011, 0(5): 798-805 |
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| Authors: | CHEN QingTao CHEN FengHua LIU GuiXia DONG XiangTing & WANG JinXian School of Chemistry Environmental Engineering Changchun University of Science Technology Changchun China School of Material Chemical Engineering Zhengzhou University of Light Industry Zhengzhou China Suzhou Institute of Nano-tech Nano-bionics Chinese Academy of Science Suzhou China |
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| Affiliation: | CHEN QingTao1,3,CHEN FengHua2,LIU GuiXia1,DONG XiangTing1 & WANG JinXian1 1 School of Chemistry and Environmental Engineering,Changchun University of Science and Technology,Changchun 130022,China 2 School of Material and Chemical Engineering,Zhengzhou University of Light Industry,Zhengzhou 450002,China 3 Suzhou Institute of Nano-tech and Nano-bionics,Chinese Academy of Science,Suzhou 215123,China |
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| Abstract: | NaYF4:Yb,Er-MWCNT-FA composite nanomaterials were obtained by conjugating the carbon nanotubes with folic acid and 2,3-dimercaptosuccinic acid functionalized NaYF4:Yb,Er nanoparticles via an amide bond. Their morphology, structures, fluorescent and target imaging properties were characterized by means of TEM, XRD, UV-Vis, PL and confocal laser scanning microscopy (CLMS). The results of CLMS demonstrated that the functional composites had a high effectiveness to detect cancerous cell lines overexpressing the... |
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| Keywords: | nanometer NaYF4:Yb/Er folic acid carbon nanotube doxorubince |
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