| 十二烷基磺酸钠增敏电化学法超灵敏地测定尿液中拓扑替康盐酸盐 |
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| 引用本文： | 李红波,李静,杨占军,徐琴,胡效亚.十二烷基磺酸钠增敏电化学法超灵敏地测定尿液中拓扑替康盐酸盐[J].中国科学:化学,2011(3):550-555. |
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| 作者姓名： | 李红波 李静 杨占军 徐琴 胡效亚 |
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| 作者单位： | 扬州大学化学化工学院;盐城工学院化学与生物工程学院; |
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| 基金项目： | 国家自然科学基金(20675071,20705030&20875081); 盐城工学院自然科学基金(XKY2009009)资助 |
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| 摘 要： | 提出了在一次性电极(改进的石墨浸蜡电极)上,利用十二烷基磺酸钠增敏电化学法亚皮摩尔级测定拓扑替康盐酸盐的方法.考察了不同种类的表面活性剂对拓扑替康盐酸盐的电化学响应.结果表明,十二烷基磺酸钠能够显著地提高其电化学响应.在优化的实验条件下,氧化峰电流跟拓扑替康盐酸盐浓度的对数在2.0×10-12至1.0×10-11mol/L和8.0×10-11至8.0×10-10mol/L范围内成线性关系,检出限为6.4×10-13mol/L.该方法用于检测尿液中的拓扑替康盐酸盐.
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| 关 键 词： | 拓扑替康盐酸盐 电分析 十二烷基磺酸钠 一次性电极 |
Sodium dodecyl sulfate sensitized electrochemical method for ultrasensitive determination of topotecan hydrochloride in urine |
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| LI HongBo,LI Jing,YANG ZhanJun,XU Qin& HU XiaoYa College of Chemistry , Engineering,Yangzhou University,Yangzhou ,China Chemistry , Biology Engineering School,Yancheng Institute of Technology,Yancheng ,China.Sodium dodecyl sulfate sensitized electrochemical method for ultrasensitive determination of topotecan hydrochloride in urine[J].Scientia Sinica Chimica,2011(3):550-555. |
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| Authors: | LI HongBo LI Jing YANG ZhanJun XU Qin& HU XiaoYa College of Chemistry Engineering Yangzhou University Yangzhou China Chemistry Biology Engineering School Yancheng Institute of Technology Yancheng China |
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| Institution: | LI HongBo1,2,LI Jing2,YANG ZhanJun1,XU Qin1& HU XiaoYa1 1 College of Chemistry and Engineering,Yangzhou University,Yangzhou 225002,China 2 Chemistry and Biology Engineering School,Yancheng Institute of Technology,Yancheng 224051,China |
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| Abstract: | A sub-picomole level topotecan hydrochloride determination method was proposed using sodium dodecyl sulfate (SDS) as sensitized reagent at a novel disposable electrode (an improved wax-impregnated graphite electrode). The effects of different kinds of surfactants were examined on the electrochemical response to topotecan hydrochloride. The results indicated the electrochemical signal was apparently improved by SDS. At optimal conditions, the oxidative peaks current increased linearly with the logarithm of c... |
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| Keywords: | topotecan hydrochloride electroanalysis sodium dodecyl sulfate (SDS) disposable electrode |
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