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DNA template-synthesized silver nanoparticles:A new platform for high-performance fluorescent biosensing of biothiols |
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| Authors: | JIN JianYu OUYANG XiangYuan LI JiShan JIANG JianHui WANG Hao WANG YongXiang & YANG RongHua Beijing National Laboratory for Molecular Sciences College of Chemistry Molecular Engineering Peking University Beijing China State Key Laboratory of Chemo/Biosensing Chemometrics Biomedical Engineering Center College of Chemistry Chemical Engineering Hunan University Changsha China |
| Affiliation: | JIN JianYu1,OUYANG XiangYuan2,LI JiShan2,JIANG JianHui2,WANG Hao1,WANG YongXiang1 & YANG RongHua1,2 1Beijing National Laboratory for Molecular Sciences,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China 2State Key Laboratory of Chemo/Biosensing and Chemometrics,Biomedical Engineering Center,College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082,China |
| Abstract: | To develop the high-performance fluorescent bio-sensors, the metal nanoparticles were employed as nanoquenchers and at- tracted reasonable attention in the design of fluorescent biosensors. In this work, silver nanoparticles (AgNPs) were obtained via reduction of Ag+ on FAM-labeled DNA template. For the tight binding between AgNPs and DNA, the tem-plate-ynthesized AgNPs turned out high quenching efficiency and could be applied as super nanoquenchers to establish the biosensing platform for fluorescent detec... |
| Keywords: | silver nanoparticles DNA template-synthesized thiols fluorescent sensing |
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