A new quantitative structure-retention relationship model for predicting chromatographic retention time of oligonucleotides |
| |
| Authors: | ZHAO Wei LIANG GuiZhao CHEN YuZhen & YANG Li Key Laboratory of Biorheological Science Technology Ministry of Education Bioengineering College Chongqing University Chongqing China |
| |
| Affiliation: | ZHAO Wei1,LIANG GuiZhao1*,CHEN YuZhen2 & YANG Li1 1Key Laboratory of Biorheological Science and Technology(Chongqing University),Ministry of Education,Bioengineering College,Chongqing University,Chongqing 400044,China 2Department of Mathematics,Henan Institute of Science and Technology,Xinxiang 453003,China |
| |
| Abstract: | An integrated approach is proposed to predict the chromatographic retention time of oligonucleotides based on quantitative structure-retention relationships(QSRR) models.First,the primary base sequences of oligonucleotides are translated into vectors based on scores of generalized base properties(SGBP),involving physicochemical,quantum chemical,topological,spatial structural properties,etc.;thereafter,the sequence data are transformed into a uniform matrix by auto cross covariance(ACC).ACC accounts for the ... |
| |
| Keywords: | oligonucleotide quantitative structure-retention relationship scores of generalized base properties auto cross covariance genetic algorithm support vector machine |
| 本文献已被 CNKI 等数据库收录！ |
|
