Review:Advances in methodology of DNA methylation assay |
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| Authors: | TIAN Tian WANG ShaoRu WU JianGuo & ZHOU Xiang State Key Laboratory of Virology Wuhan University Wuhan China College of Chemistry Molecular Sciences China |
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| Institution: | TIAN Tian1,2,WANG ShaoRu2,WU JianGuo1 & ZHOU Xiang1,2 1State Key Laboratory of Virology,Wuhan University,Wuhan 430000,China 2College of Chemistry and Molecular Sciences,China |
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| Abstract: | DNA methylation is one of the most signaficant epigenetic events which greatly influence gene activation, gene imprinting, chromatin stability, and so on. The level of methylation in genome and certain regions should be in a normal range, because any variation would cause physiological dysfunction. In account of essential roles of DNA methylation in the living system, the detection of methylation in both overall genome and specific positions has drawn great interest. So far many biological and chemical meth... |
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| Keywords: | DNA methylation detection of DNA methylation disease diagnosis epigenetic research |
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