| 生物大分子层层组装:从生物分子的固定,界面控释到细胞外基质模拟 |
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| 引用本文： | 任科峰,沈利燕,孙婕衎,孙一新,付轲,计剑. 生物大分子层层组装:从生物分子的固定,界面控释到细胞外基质模拟[J]. 中国科学:化学, 2011, 0(2): 239-249 |
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| 作者姓名： | 任科峰 沈利燕 孙婕衎 孙一新 付轲 计剑 |
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| 作者单位： | 高分子合成与功能构造教育部重点实验室浙江大学高分子科学与工程学系; |
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| 基金项目： | 国家自然科学基金项目(50373036,50830106); 教育部“新世纪优秀人才计划”(NCET-05-05278); 863计划(2006AA03Z329)的资助 |
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| 摘 要： | 随着超分子科学、界面科学方法技术与生物医用材料科学的交叉与渗透,生物大分子层层组装已成为生物医用材料界面设计和制备的重要方法.本论文从采用生物大分子层层组装进行生物活性分子固定、界面控释涂层构建到细胞外基质结构功能模拟3个相互关联的研究视角,结合该领域国内外和本课题组的研究成果,对该领域的研究进展进行了综述,并对生物大分子层层组装作为一种生物医用材料界面设计制备新方法的未来进行了展望.
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| 关 键 词： | 层层组装 生物医用材料 材料界面修饰 细胞外基质模拟 |
Layer-by-layer self-assembly of biomacromolecules:From biomolecules immobilization,local delivery to a robust tool to mimic extracelluar matrix |
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| REN KeFeng,SHEN LiYan,SUN JieKan,SUN YiXin,FU Ke , JI Jian MOE Key Laboratory of Macromolecular Synthesis , Functionalization. Layer-by-layer self-assembly of biomacromolecules:From biomolecules immobilization,local delivery to a robust tool to mimic extracelluar matrix[J]. Scientia Sinica Chimica, 2011, 0(2): 239-249 |
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| Authors: | REN KeFeng SHEN LiYan SUN JieKan SUN YiXin FU Ke & JI Jian MOE Key Laboratory of Macromolecular Synthesis Functionalization |
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| Affiliation: | REN KeFeng,SHEN LiYan,SUN JieKan,SUN YiXin,FU Ke & JI Jian MOE Key Laboratory of Macromolecular Synthesis and Functionalization,Department of Polymer Science and Engineering,Zhejiang University,Hangzhou 310027,China |
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| Abstract: | Along with the interdisciplinary development of supermolecular science,materials science and biomaterial,layer-by-layer self-assembly has been explored as a robust method in the surface engineering of biomedical materials and device.In this context,a systematic review of current research on layer-by-layer self-assembly of biomacromolecules,from biomolecules immobilization,local delivery to a robust tool to mimic extracelluar matrix,is presented.Future developments in the field of biomedical applications of ... |
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| Keywords: | layer-by-layer self-assembly biomaterials surface modification extracellur matrix |
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