Synthesis and antiviral activity of nucleoside analogs based on 1,2,4-triazolo[3,2-<Emphasis Type="Italic">c</Emphasis>][1,2,4]triazin-7-ones |
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| Authors: | V L Rusinov O N Chupakhin S L Deev T S Shestakova E N Ulomskii L I Rusinova O I Kiselev E G Deeva |
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| Institution: | 1.B. N. Eltsyn Ural State Technical University — UPI,Ekaterinburg,Russian Federation;2.I. Ya. Postovsky Institute of Organic Synthesis,Ural Branch of the Russian Academy of Sciences,Ekaterinburg,Russian Federation;3.Influenza Research Institute,Russian Academy of Medical Sciences,St.-Petersburg,Russian Federation |
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| Abstract: | Nucleoside analogs containing hydroxybutyl, hydroxyethoxymethyl, allyloxymethyl, and propargyloxymethyl fragments were synthesized
based on 1,2,4-triazolo3,2-c]1,2,4]triazin-7-ones isosteric to purine bases. Some of the compounds obtained inhibit in vitro reproduction of influenza and respiratory syncytial virus infection. |
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