Yb(OTf)3催化苯乙酮、芳香醛和芳香胺的Mannich反应: 三组分“一锅法”合成β-氨基酮衍生物 |
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引用本文: | 王利民,韩建伟,盛佳,樊兆玉,田禾. Yb(OTf)3催化苯乙酮、芳香醛和芳香胺的Mannich反应: 三组分“一锅法”合成β-氨基酮衍生物[J]. 有机化学, 2005, 25(5): 591-594 |
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作者姓名: | 王利民 韩建伟 盛佳 樊兆玉 田禾 |
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作者单位: | (华东理工大学精细化工研究所结构可控先进功能材料教育部重点实验室 上海 200237) |
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摘 要: | 报道了稀土化合物Yb(OTf)3催化的苯乙酮、芳香醛和芳香胺Mannich反应, 三组分“一锅法”合成了一系列的β-氨基酮衍生物. 该方法操作简单、条件温和、产率较高、催化剂可重复使用, 且对环境友好.
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关 键 词: | Yb(OTf)3 Mannich反应 芳香醛 芳香胺 β-氨基酮衍生物 |
收稿时间: | 2004-08-02 |
修稿时间: | 2004-11-23 |
Yb(OTf)3 Catalyzed Mannich Reaction of Acetophe-none withAromatic Aldehydes and Aromatic Amines: Three Component One-pot Synthesis of β-Amino Ketone Derivatives |
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Affiliation: | (Institute of Fine Chemicals, Laboratory for Advanced Materials, East China University of Science and Technology,Shanghai 200237) |
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Abstract: | The three component “one-pot” Mannich reaction of acetophenone with aromatic aldehydes and aromatic amines catalyzed by Yb(OTf)3 afforded the corresponding β-amino ketone derivatives in high yields under mild conditions. The catalyst Yb(OTf)3 was recycled easily and thus regarded as environmentally-friendly catalyst. |
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Keywords: | Yb(OTf)3 Mannich reaction aromatic aldehyde aromatic amine β-amino ketone derivative |
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