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Asymmetric hydrogenation of methyl 3,5-dioxohexanoate catalyzed by ru-binap complex: a short step asymmetric synthesis of dihydro-60methyl-2-H-pyran-2-one |
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| Authors: | Liming Shao Toshiyuki Seki Hiroyuki Kawano Masahiko Saburi |
| Affiliation: | Department of Industrial Chemistry, Faculty of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113 Japan |
| Abstract: | Hydrogenation of methyl 3,5-dioxohexanoate 3 using Ru2Cl4((R) or (S)-binap)2(NEt3) as the catalyst gave dominantly anti 3,5-dihydroxyester 9, which was then converted into unsaturated lactone 4. The pathway of the hydrogenation reaction was also investigated. |
| Keywords: | β,δ-diketoester Ru-binap catalyst asymmetric hydrogenation asymmetric synthesis lactone. |
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