Direct enantioselective access to 4-substituted tetrahydroquinolines by catalytic asymmetric transfer hydrogenation of quinolines |
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| Authors: | Rueping Magnus Theissmann Thomas Stoeckel Mirjam Antonchick Andrey P |
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| Institution: | Institute of Organic Chemistry, RWTH Aachen University, Landoltweg, 1, D-52074, Aachen, Germany. Magnus,Rueping@rwth-aachen.de |
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| Abstract: | A convenient protocol for the enantioselective synthesis of 4-substituted tetrahydroquinolines has been developed. Chiral BINOL phosphoric acids promote the reduction of a wide range of 4-substituted quinolines with Hantzsch esters with good to high levels of enantioselectivity. |
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