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A cross-metathesis approach to the synthesis of new etretinate type retinoids, ethyl retinoate and its 9Z-isomer |
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| Authors: | Jadwiga MajJacek W Morzycki Lucie RárováGrzegorz Wasilewski Agnieszka Wojtkielewicz |
| Institution: | a Institute of Chemistry, University of Bia?ystok, Pi?sudskiego 11/4, Bia?ystok 15-443, Poland b Faculty of Science, Palacký University, Šlechtitelu 11, Olomouc 783 71, Czech Republic |
| Abstract: | Two aromatic retinoids were synthesized from styrene derivatives using a novel strategy with a cross-metathesis reaction as a key step. The biological activity of the new etretinate analogues was tested. Cross-metathesis reactions were also employed for the preparation of ethyl retinoate and its 9Z-isomer via the C15 + C5 route. |
| Keywords: | Cross-metathesis Retinoids Etretinate analogues Polyenes |
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