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Microwave-assisted silica-supported aluminum chloride-catalyzed Friedel-Crafts alkylation |
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| Authors: | Laurine R ZuppVeronica L Campanella DiAndra M RudzinskiFrançois Beland Ronny Priefer |
| Institution: | a College of Pharmacy, Western New England University, Springfield, MA 01119, USA b Department of Chemistry, Biochemistry, and Physics, Niagara University, NY 14109, USA c SiliCycle Incorporated, Quebec City, QC, Canada G1P 4S6 |
| Abstract: | Microwave irradiation is a popular method in organic synthesis to achieve high yields in shorter reaction times. This decreases total ‘man-hours’ in a synthetic setting. Another technique used in organic chemistry to decrease manual manipulations, is solid support reagents. The benefits of this approach is that upon completion of a reaction, a simple filtration can be performed which expedites the work-up and also produces less organic waste. Friedel-Crafts alkylation has been explored using microwave chemistry as well as with solid-supported reagents. In comparison with traditional heating, as well as with AlCl3, superior yields were observed with silica-gel bound aluminum chloride (Si-AlClx) when microwave irradiated for only 5 min. |
| Keywords: | Friedel-Crafts alkylation Microwave irradiation Silica-gel bound aluminum chloride |
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