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Synthesis of bis(indolyl)methanes using silica gel as an efficient and recyclable surface |
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| Authors: | Samuel R. Mendes,Samuel ThurowMargiani P. Fortes,Filipe PenteadoEder J. Lenardã o,Diego AlvesGelson Perin,Raquel G. Jacob |
| Affiliation: | a GAPAM, Departamento de Química, Universidade do Estado de Santa Catarina, Joinville, SC, Brazil b LASOL, Universidade Federal de Pelotas, UFPel, Pelotas, RS, Brazil c Universidade Federal de Santa Maria, UFSM, Santa Maria, RS, Brazil |
| Abstract: | Here we describe a simple, clean, and efficient solvent-free protocol for the synthesis of bis(indolyl)methanes promoted by silica gel. The products were obtained in good to excellent yields through the reaction of indoles with cyclohexanone and a range of aldehydes. The silica gel was easily recovered and utilized for further reactions without loss of activity. |
| Keywords: | Indole Bis(indolyl)methanes Silica gel Solvent free |
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