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Facile and efficient generation of quinolone amides from esters using aluminum chloride |
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| Authors: | Michael K. Schwaebe David M. RyckmanJohnny Y. Nagasawa Fabrice PierreAnne Vialettes Mustapha Haddach |
| Affiliation: | Cylene Pharmaceuticals, Inc., 5820 Nancy Ridge Dr. Suite 200, San Diego, CA 92121, USA |
| Abstract: | Quinolone esters are readily converted into the corresponding amides using aluminum chloride at room temperature in excellent yields and purities. The method is both general and scalable to multi-kilogram quantities. |
| Keywords: | Amide Ester Quinolone Aluminum chloride Direct conversion Lewis acid Acylation |
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