LC Analysis of Oxytetracycline and Chlortetracycline: Application for In Vitro Bio-Equivalence Study of Veterinary Medicines |
| |
Authors: | Francesca Mancini Cristina Cavallari Paola Filippi Lorenzo Rodriguez Anna Maria Di Pietra Vincenza Andrisano |
| |
Affiliation: | 1. Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy 2. Industria Italiana Integratori TREI S.p.A, Viale Corassori 62, 41100, Modena, Italy
|
| |
Abstract: | A liquid chromatographic method has been applied for the analysis of two antibiotics widely used in the veterinary field, oxytetracycline dihydrate and chlortetracycline hydrochloride in premixes for medicated feeding stuffs for veterinary use. In particular, the validated method was employed to study the releasing profile of each drug from two formulations, a commercially available and a new formulation, having different excipient composition. The dissolution profiles obtained from the chromatographic analysis allowed to verify the in vitro bio-equivalence of the commercial and the new formulations for oxytetracycline and chlortetracycline. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|