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Separation of Enantiomers and Control of Elution Order of β-Lactams by GC Using Cyclodextrin-Based Chiral Stationary Phases |
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| Authors: | Ke Huang Daniel W Armstrong Eniko Forro Ferenc Fulop Antal Peter |
| Institution: | 1. Chemistry and Biochemistry Department, University of Texas at Arlington, Arlington, TX, 76019, USA 2. Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, Hungary 3. Department of Inorganic and Analytical Chemistry, University of Szeged, Szeged, Hungary |
| Abstract: | Enantiomers of 19 racemic β-lactams, with 3 and 4-position substitutions, were separated using gas chromatography. Excellent results were achieved on derivatized cyclodextrin-based GC chiral stationary phases (CSPs). All 19 compounds were baseline separated, most with high resolution factors. The Chiraldex G-TA was found to be the most powerful CSP with the broadest enantioselectivity, while Chiraldex B-DM produced the fastest separations for most of the compounds assayed. Results obtained in this work suggest that GC can serve as a potential method for the enantiomeric separation of sufficiently volatile solid β-lactams. |
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