Immobilization of synthetic glycopeptides on polymeric supports

The synthesis of the 6-aminohexyl -glycoside of O-(N-acetylglucosaminyl)-(14)-MDP (GMDP) is described. Conjugates with polyacrylamide, including lipophilic conjugates (containing phosphatidylethanolamine residues) and biotinylated polymeric probes with MDP specificity have been obtained on the basis of -spacered glycopeptides. Conjugates of MDP with dextran have also been synthesized.Simferopol' State University, 4 Yaltinskaya ul., Simferopol', Crimea, Ukraine. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 104–111, January–February, 1998.