Total synthesis of hapalindoles J and U |
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Authors: | Rafferty Ryan J Williams Robert M |
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Affiliation: | Department of Chemistry, Colorado State University, 1301 Center Avenue, Fort Collins, Colorado 80523, United States. |
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Abstract: | The total synthesis of D,L-hapalindoles J and U has been accomplished. Hapalindole J was prepared in 11% overall yield over 11 synthetic steps and hapalindole U was prepared in 25% overall yield over 13 synthetic steps from commercially available materials. The route employs a novel silyl ether-based strategy for accessing the 6:5:6:6 ring system of the hapalindoles rapidly and in good yields. |
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