Synthetic fragments of antigenic lipophosphoglycans from Leishmania major and Leishmania mexicana and their use for characterisation of the Leishmania elongating alpha-D-mannopyranosylphosphate transferase |
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| Authors: | Higson Adrian P Ross Andrew J Tsvetkov Yury E Routier Françoise H Sizova Olga V Ferguson Michael A J Nikolaev Andrei V |
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| Affiliation: | Faculty of Life Sciences, Division of Biological Chemistry and Molecular Microbiology, University of Dundee (Carnelley Building), Dundee DD1 4HN, Scotland, UK. |
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| Abstract: | The phosphorylated branched heptasaccharides 7 and 8, the octasaccharide 9 and the phosphorylated trisaccharides 5 and 6, which are fragments of the phosphoglycan portion of the surface lipophosphoglycans from Leishmania mexicana (5) or L. major (6-9), were synthesised by using the glycosyl hydrogenphosphonate method for the preparation of phosphodiester bridges. The compounds were tested as acceptor substrates/putative inhibitors for the Leishmania elongating alpha-D-mannosylphosphate transferase. |
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| Keywords: | carbohydrates glycosides glycosyl phosphates inhibitors lipophosphoglycans |
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