| 西尼地平核磁共振碳谱氢谱的谱峰归属 |
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| 引用本文： | 张家海,杜定准,吴季辉.西尼地平核磁共振碳谱氢谱的谱峰归属[J].分析化学,2003,31(9):1044-1047. |
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| 作者姓名： | 张家海 杜定准 吴季辉 |
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| 作者单位： | 1. 中国科技大学生命科学院,中国科学院结构生物学重点实验室,合肥,230026
2. 中国科技大学化学与材料科学学院,合肥,230026 |
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| 基金项目： | 国家 973资助项目 (No .G19990 75 60 5 ) |
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| 摘 要： | 利用普通1H-NMR，13C-NMR，极化转移谱(DEPT)以及同核相关谱(COSY)、异核相关谱(HSQC)，特别是远程偶合谱(HMBC)等多种核磁研究方法对新型的血管扩张药西尼地平的1H、13C信号进行完全归属。对由于分子结构对称而引起的化学位移相差最小为0．94Hz的两个碳加以区分，解决了由于样品的近似对称性而导致几组谱峰难以归属的问题。
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| 关 键 词： | 西尼地平 核磁共振 碳谱 氢谱 谱峰 近似对称性 同核相关 异核相关 远程偶合 药理作用 抗动脉粥样硬化 |
Identification for the Hydrogen and Carbon Spectra of Cilnidipine by Nuclear Magnetic Resonance |
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| Zhang Jiahai ,Du Dingzhun ,Wu Jihui.Identification for the Hydrogen and Carbon Spectra of Cilnidipine by Nuclear Magnetic Resonance[J].Chinese Journal of Analytical Chemistry,2003,31(9):1044-1047. |
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| Authors: | Zhang Jiahai Du Dingzhun Wu Jihui |
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| Institution: | Zhang Jiahai *1,Du Dingzhun 2,Wu Jihui 1 1 |
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| Abstract: | The structure of the title compound was identified by 1H , 13C, DEPT (distortionless enhancement by polarization transfer) and various two dimensional nuclear magnetic resonance spectroscopy, such as COSY (correlation spectroscopy), HSQC (heteronuclear correlation spectroscopy) and HMBC (heteronuclear multiple bond correlation spectroscopy). All the chemical shifts of 1H and 13C were assigned. The high efficiency of the HMBC in the structure research of complex and high symmetric compounds was discussed. |
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| Keywords: | Cilnidipine distortionless enhancement by polarization transfer homonuclear correlation spectroscopy heteronuclear correlation spectroscopy heteronuclear multiple bond correlation spectroscopy |
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