Synthesis and Crystal Structure of (E)-2-phenyl-6,7dihydrobenzofuran-4(5H)-one O-cyanomethyl Oxime |
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作者姓名: | 金蕾 方胡彪 曹成桥 黄年玉 邹坤 汪鋆植 |
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作者单位: | Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Sciences, China Three Gorges University;Hubei Tujia Institute of Medicine; |
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基金项目: | Supported by the National Natural Science Foundation of China(Nos.21102084,21272136,31070313); Scientific and Technological Research Project of Hubei Provincial Department of Education(No.Q20111210); Science Foundation of China Three Gorges University(No.KJ2010B001) |
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摘 要: | A pair of E/Z-isomers of 2-phenyl-6,7-dihydrobenzofuran-4(5H)-one O-cyanomethyl oxime,C16H14N2O2,as potential drugs for treating peptic ulcer and other acid-related diseases have been synthesized and characterized by IR,MS and NMR spectra.Meanwhile,the crystal of IIIa was obtained and determined by X-ray single-crystal diffraction.Crystal data: monoclinic system,space group P21 /c,a = 8.423(8),b = 19.596(16),c = 8.770(8),β = 107.750(12)°,V = 1379(2)3,Z = 4,F(000) = 560,Dc = 1.283 g/cm3,μ = 0.086 mm 1,R = 0.0681 and wR = 0.2029 for 14472 independent reflections(Rint = 0.0782) and 2428 observed ones(I 2σ(I)).
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关 键 词: | 晶体结构 合成 苯基 X-射线单晶衍射 二氢苯并呋喃 核磁共振光谱 肟 氰 |
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