Anchorage-independent growth with JB6 cells exposed to 60 Hz magnetic fields at several flux densities |
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| Institution: | 1. National Center for Toxicological Research/FDA, Jefferson, AR 72079, USA;2. Center for Devices and Radiological Health/FDA, Rockville, MD 20857, USA;1. Department of Chemistry, Eram Institute of Higher Education, P. O. Box 71957-46733, Shiraz, Iran;2. Faculty of Naval Aviation, Malek Ashtar University of Technology, Iran |
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| Abstract: | JB6 clone 41 cells have previously been shown to respond to a 1.1. mT magnetic field with increased growth under anchorage-independent (AI) conditions. Here we have examined the AI growth-response simultaneously at three lower flux densities and without an applied field. Fields were generated with Helmholtz coils held in water-jacketed CO2 incubators. Colony growth (60 μm diameter) was scored at 8 and 14 days after seeding cells in soft agar. Zero-field experiments conducted simultaneously in several incubators produced uniform counts (about 1 per 103 cells seeded). For 14-day exposures at 100 μT, 10 μT and 1μT, four of four, six of six, and two of three experiments, respectively, showed a significantly increased colony number (p < 0.02), with the ratio of field-exposed to control colonies varying from 1.2 to 3.2. Thus, an effect of magnetic fields at flux densities approaching environmental levels of exposure has been demonstrated. |
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