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Macrocyclic Cyclopropenes by Highly Enantioselective Intramolecular Addition of Metal Carbenes to Alkynes |
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| Authors: | Michael P Doyle Doina G Ene Chad S Peterson Vince Lynch |
| Abstract: | The intramolecular addition of a diazo ester group to a triple bond in the presence of chiral dirhodium(II ) carboxamidate catalysts gives macrocyclic lactones with a fused cycloproprene ring Eq. (a)]. This efficient reaction is characterized by high enantiocontrol (up to 98% ee) and chemoselectivity. |
| Keywords: | Asymmetric synthesis Carbene complexes Homogeneous catalysis Macrocycles Rhodium |