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Monitoring Chemical Warfare Agents: A New Method for the Detection of Methylphosphonic Acid |
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| Authors: | Jon A Ashley Chao-Hsiung Lin Peter Wirsching Kim D Janda |
| Abstract: | Methylphosphonic acid (MPA) is the degradation product of many chemical warfare agents. The convenient detection of this substance would aid in field testing to confirm illicit manufacture and use of banned chemical weapons. Efficient functionalization of MPA with an aromatic diazo compound allowed binding by monoclonal antibodies elicited by using an analogous hapten (see scheme). An ELISA assay was rapid, sensitive, and specific. |
| Keywords: | Analytical methods Chemical warfare agents Immunoassays Methyl phosphonic acid Phosphorus |