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α-Alkyl-α-Amino-β-Lactam Peptides: Design,Synthesis, and Conformational Features |
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| Authors: | Claudio Palomo Jesus M Aizpurua Ana Benito Regina Galarza Uttam K Khamrai Jordi Vazquez Beatriz de Pascual-Teresa Pedro M Nieto Anthony Linden |
| Abstract: | Remarkable asymmetric induction is achieved in the alkylation of the lithium enolate of the β-lactam 1 . This allows the first time access to a new family of peptidomimetics 2 with predictable conformational constraints. |
| Keywords: | Alkylations Conformation analysis Lactams Peptides Peptidomimetics |