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Novel Fluorescent Probes for Singlet Oxygen |
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| Authors: | Naoki Umezawa Kumi Tanaka Yasuteru Urano Kazuya Kikuchi Tsunehiko Higuchi Tetsuo Nagano |
| Abstract: | The first fluorescent chemical traps for 1 O 2 have been developed. DPAXs react specifically with 1O2 to yield the corresponding endoperoxides, DPAX-EPs (see scheme; X = H, Cl, F). DPAXs scarcely fluoresce, while DPAX-EPs are strongly fluorescent. Since the fluorescence of these probes is unaffected by H2O2, superoxide, and nitric oxide, they are useful for the selective detection of 1O2 in biological systems. |
| Keywords: | Dyes Endoperoxides Fluorescence spectroscopy Singlet oxygen |