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Integrated Chemical Process: One-Pot Aromatization of Cyclic Enones by the Double Elimination Methodology
Authors:Akihiro Orita  Jayamma Yaruva  Junzo Otera
Abstract:A variety of aromatic hydrocarbons bearing multiple alkyl substituents are accessible with perfect regiocontrol in a one-pot reaction starting from cyclohexenones and their aromatic analogues Eq. (1)]. The present methodology can be further extended to the synthesis of polycyclic aromatic hydrocarbons. The drawbacks encountered in the Friedel–Crafts reaction are resolved since the reaction proceeds under basic conditions.
Keywords:Arenes  Eliminations  Enones  Integrated chemical process  One-pot reaction
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