Synthesis and Biological Evaluation of a Cyclo-β-tetrapeptide as a Somatostatin Analogue

Short β -peptides can mimic natural peptide hormones , as has been shown with a cyclo-β-tetrapeptide ( 1 ) that displays micromolar affinity to human somatostatin receptors. β-Peptides are thus a promising new class of peptidomimetics with potential high bioavailability due to their excellent resistance against proteases.