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Total Synthesis of (−)-Bafilomycin A1: Application of Diastereoselective Crotylboration and Methyl Ketone Aldol Reactions |
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| Authors: | Karl A Scheidt Akihiro Tasaka Thomas D Bannister Michael D Wendt William R Roush |
| Abstract: | A careful orchestration of protecting groups is an essential requirement for the total synthesis of the macrolide antibiotic bafilomycin A1 ( 1 ). Key steps were the Suzuki cross-coupling reaction of two advanced, suitably protected intermediates prior to closure of the macrocycle, as well as a highly stereoselective methyl ketone aldol reaction. |
| Keywords: | Aldol reactions Asymmetric synthesis Bafilomycin Total synthesis |