Asymmetric Synthesis of Novel Ferrocenyl Ligands with Planar and Central Chirality |
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Authors: | Dieter Enders,René Peters,René Lochtman,Gerhard Raabe |
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Abstract: | A stereogenic center at the position β to the metallocene backbone is present in ferrocenyl ligands 2 , which are interesting for asymmetric catalysis. These planar-chiral compounds are accessible for the first time by a highly diastereoselective and enantioselective synthesis (de=93–97 %; ee≥96 %) from the ferrocenyl ketones 1 . A variety of donor groups (E1=Ph2P⋅BH3, SMe, SiPr; E2=SMe, STol, SePh, Ph2P⋅BH3, iPr2P⋅BH3) can be introduced as electrophiles. Tol=tolyl=CH3C6H4. |
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Keywords: | Asymmetric synthesis Chelates Chiral auxiliaries Ferrocenyl ligands Hydrazones |
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