An overview on the standardization of chromatographic methods for screening analysis in toxicology by means of retention indices and secondary standards |
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| Authors: | Maciej Bogusz Jan Piet Franke Rokus A de Zeeuw and Manfred Erkens |
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| Institution: | (1) Institute of Forensic Medicine, Klinikum RWTH, W-5100 Aachen, Germany;(2) University Centre for Pharmacy, Department of Analytical Chemistry and Toxicology, University of Groningen, NL-9713 AW Groningen, The Netherlands |
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| Abstract: | Summary A review is presented on the methods of standardization of HPLC data as used in systematic toxicological analysis. In straight-phase HPLC, the best results were obtained with a series of selected drugs as retention standards. In reversed-phase HPLC, various retention index systems were introduced. However, these systems alone cannot compensate large differences in selectivities of nominally identical, but commercially different reversed-phase column packings. Much better results were achieved with selected drugs as retention index markers. The practical applicability of such a standardized HPLC system is demonstrated.Part I see 1]Dedicated to Prof. Dr. Dr. Marika Geldmacher-von Mallinckrodt in recognition of her pioneering contributions in clinical and forensic toxicology |
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