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Novel Glycolipids Based on Cyclodextrins |
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| Authors: | Stéphane Moutard Bruno Perly Paul Godé Gilles Demailly Florence Djedaïni-Pilard |
| Affiliation: | (1) Service de Chimie Moléculaire, CEA/Saclay DSM/DRECAM, F-91191 Gif sur Yvette, Cedex, France;(2) Laboratoire des Glucides, Université de Picardie-Jules Verne, 33 rue St Leu, F-80039 Amiens, France |
| Abstract: | Novel amphiphilic cyclodextrins have been prepared by grafting a phospholipid on a modified cyclodextrin through a spacing arm to combine the selectivity in size of cyclodextrins and the transport properties of phospholipids. Synthesis and full characterization by NMR and mass spectrometry have been performed. The aggregation process in water has been characterized by light scattering, DSC and 31P NMR. This compound appears to assemble into large objects and displays a very low CMC. The detergent properties of the phospholipidyl-cyclodextrins have been evaluated. |
| Keywords: | amphiphilic cyclodextrin detergent properties self-organization synthesis |
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