Identification of isocephalomannine in the presence of cephalomannine isomers and alkali metal ion adducts in a paclitaxel active pharmaceutical ingredient using electrospray tandem mass spectrometry |
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Authors: | Vivekanandan Kannan Swamy Madugundu Guru Prasad Sudhanand Mukherjee Rama Burman Anand C |
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Affiliation: | Mass Spectrometry Laboratory, Dabur Research Foundation, 22 Site IV, Sahibabad, UP, 201010, India. vivekanandank@dabur.com |
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Abstract: | A strategy is developed for the identification of isocephalomannine in the presence of alkali metal ion adducts and other cephalomannine isomers in a paclitaxel active pharmaceutical ingredient. Intact molecular ion analyses and a sub-structural study have been performed for the differentiation of isocephalomannine (2-debenzoylpaclitaxel-2-pentenoate) from cephalomannine and 7-epi-cephalomannine. A comparative study of the cephalomannine isomers was carried out using molecular ions (MS) and fragmentation patterns (MS/MS) for sub-structural analysis. An attempt has been made to identify isocephalomannine in Cremophor(R) EL formulations. |
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