Hydropyrolysis as a preparative method for the compound-specific carbon isotope analysis of fatty acids |
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Authors: | Sephton Mark A Meredith Will Sun Cheng-Gong Snape Colin E |
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Institution: | Centre for Earth, Planetary, Space and Astronomical Research (CEPSAR), Earth Sciences, Open University, Milton Keynes MK7 6AA, UK. m.a.sephton@imperial.ac.uk |
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Abstract: | Compound-specific stable carbon isotope analysis by gas chromatography/combustion/isotope ratio mass spectrometry is an effective and risk-free means of investigating fatty acid metabolism. Straightforward analysis, however, leads to poor chromatographic resolution, while derivatization adds carbon thereby corrupting the starting stable isotopic composition. Hydropyrolysis is a new approach which defunctionalizes fatty acids to yield the corresponding n-alkanes thus retaining the carbon skeleton intact and improving chromatography, allowing the faithful measurement of carbon isotope ratios. |
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