Contribution of constitutively proliferating precursor cell subtypes to dentate neurogenesis after cortical infarcts |
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Authors: | Silke Keiner Josephine Walter Julia Oberland and Christoph Redecker |
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Institution: | 1.Hans-Berger-Clinic for Neurology,University Hospital Jena,Jena,Germany |
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Abstract: | Background It is well known that focal ischemia increases neurogenesis in the adult dentate gyrus of the hippocampal formation but the
cellular mechanisms underlying this proliferative response are only poorly understood. We here investigated whether precursor
cells which constitutively proliferate before the ischemic infarct contribute to post-ischemic neurogenesis. To this purpose,
transgenic mice expressing green fluorescent protein (GFP) under the control of the nestin promoter received repetitive injections
of the proliferation marker bromodeoxyuridine (BrdU) prior to induction of cortical infarcts. We then immunocytochemically
analyzed the fate of these BrdU-positive precursor cell subtypes from day 4 to day 28 after the lesion. |
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