2-aryl-N-tosylazetidines as formal 1,4-dipoles for [4 + 2] cycloaddition reactions with nitriles: an easy access to the tetrahydropyrimidine derivatives |
| |
Authors: | Prasad B A Bhanu Bisai Alakesh Singh Vinod K |
| |
Affiliation: | Department of Chemistry, Indian Institute of Technology, Kanpur, 208 016, India. |
| |
Abstract: | [reaction: see text] A new synthetic route to 2-aryl-N-tosyl azetidines has been developed starting from N-tosylarylaldimines in two steps in an overall yield of 63-70%. A formal [4 + 2] cycloaddition of these 2-aryl-N-tosylazetidines with nitriles in the presence of BF3.OEt2 has been described for the synthesis of substituted tetrahydropyrimidines. It is proposed that the reaction proceeds in Ritter fashion. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|