| Synthesis and Antibacterial Activity of New Cephalosporin Compounds |
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| 引用本文： | De Cai FU Feng Ming CHU Zong Ru GUO. Synthesis and Antibacterial Activity of New Cephalosporin Compounds[J]. 中国化学快报, 2005, 16(10): 1305-1308 |
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| 作者姓名： | De Cai FU Feng Ming CHU Zong Ru GUO |
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| 作者单位： | [1]College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018 [2]Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050 |
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| 摘 要： | The fourth generation cephalosporin cefepime I exhibited potent antibacterial activity with board antibacterial spectrum1,2.Based on the structure of cefepime,we synthesized its analogs Ia having fluoro atom at the aminothiazolyl oxime moiety at the7-position of the cephem nucleus,and Ib possessing1-(2-fluoroethyl)pyrrolidium methyl group at the3-position.It was reported that cephalosporin derivatives with a quaternary ammonium moiety at the3-position of the cephem nucleus,showed enhanced ant…
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| 关 键 词： | 头孢菌素 合成方法 抗菌性 药物 |
| 收稿时间： | 2004-12-28 |
Synthesis and Antibacterial Activity of New Cephalosporin Compounds |
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| De;Cai;FU;Feng;Ming;CHU;Zong;Ru;GUO. Synthesis and Antibacterial Activity of New Cephalosporin Compounds[J]. Chinese Chemical Letters, 2005, 16(10): 1305-1308 |
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| Authors: | De Cai FU Feng Ming CHU Zong Ru GUO |
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| Abstract: | Five new cephalosporin compounds were designed and synthesized, and the antibacterial activities were evaluated by the standard serial 2-fold agar dilution method in vitro. The results showed that the activities of the compounds Ia and lb against ESBL E. coli and K. pneumoniae are comparable to those of Cefepime. |
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| Keywords: | Cephalosporin synthesis antibacterial activities. |
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