| 将源药包覆到聚己内酯超细纤维的芯部 |
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| 引用本文： | 黄争鸣,杨爱昭.将源药包覆到聚己内酯超细纤维的芯部[J].高分子学报,2006(1):48-52. |
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| 作者姓名： | 黄争鸣 杨爱昭 |
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| 作者单位： | 固体力学教育部重点实验室,同济大学航空航天与力学学院,上海,200092 |
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| 摘 要： | 采用同轴共纺技术,分别将白藜芦醇(Resveratrol,RT)和硫酸庆大霉素(Gentamycin Sulfate,GS)源药包覆在生物可降解的聚己内酯(PCL)超细(直径为几百纳米)纤维芯部.研究了这种纤维的制备过程以及它们的微观结构.这种复合纳米纤维可在医疗新产品开发中发挥作用,如用于制备新的羊肠线(体内手术伤口缝合线)或伤口敷布.
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| 关 键 词： | 复合纳米纤维 静电纺丝 微观结构 TEM SEM |
| 收稿时间： | 2004-07-09 |
| 修稿时间： | 2004-11-23 |
ENCAPSULATION OF PURE DRUGS INTO THE CENTRAL PART OF POLYCAPROLACTONE ULTRAFINE FIBERS |
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| HUANG Zhengming,YANG Aizhao.ENCAPSULATION OF PURE DRUGS INTO THE CENTRAL PART OF POLYCAPROLACTONE ULTRAFINE FIBERS[J].Acta Polymerica Sinica,2006(1):48-52. |
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| Authors: | HUANG Zhengming YANG Aizhao |
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| Abstract: | Electrospinning has been recognized as an efficient method for fabricating continuous nanofibers for,(e.g.,)biomedical applications.With a modified co_axial electrospinning technique,a pencil_like,core_shell composite nanofiber can be obtained.In this paper,two pure drugs,resveratrol and gentamycin sulfate,were encapsulated respectively into the cores of biodegradable polycaprolactone(PCL) ultrafine fibers with a diameter down to hundreds of nanometers.The fabrication process of these nanofibers and their micro_structural characteristics were investigated.Such composite nanofibers can be useful in controlled drug release and in the development of new medical devices as absorbable sutures inside human body or wound dressing materials. |
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| Keywords: | Composite nanofibers Electrospinning Micro_structure TEM SEM |
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